Peptide design. Helix–helix motifs in synthetic sequences
نویسندگان
چکیده
منابع مشابه
Peptide design. Helix–helix motifs in synthetic sequences
Two centrally positioned á-aminoisobutyryl (Aib) residues have been used to stabilize distinct heptapeptide helical segments in the 15-residue synthetic sequence Boc-Met-Ala-Leu-Aib-Val-Ala-LeuAcp-Val-Ala-Leu-Aib-Val-Ala-Phe-OMe. The helices are connected by the flexible linker å-aminocaproic acid (Acp). NMR studies in CDCl3 establish helical conformations for both independent segments as evide...
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ژورنال
عنوان ژورنال: Journal of the Chemical Society, Perkin Transactions 2
سال: 1997
ISSN: 0300-9580,1364-5471
DOI: 10.1039/a700624a